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Is this a voided specimen or was she catheterized? I think it's worrisome for...something bad. Any additional history, like a renal or bladder mass?

----Comment by: kyouens on 2/28/2007 6:41:15 PM

So that is an important consideration: if this is voided urine, then there should not be clusters of transitional epithelium as we see here. The nuclei look fairly low-grade, with smooth nuclear contours and mild size variation. The cells on the right edge show degenerate changes (smudgy, dark chromatin), which can be confused for hyperchromasia of malignancy. Bottom line: I favor a low grade papillary urothelial carcinoma if this is a voided specimen. If this is from instrumentation, then this could just be reactive atypia.

----Comment by: BigDaddy on 2/28/2007 7:13:34 PM

What he said.

----Comment by: kyouens on 3/1/2007 10:26:14 AM

This is voided urine. Thanks for the insight. I'll update.

----Comment by: PathDoc15 on 3/1/2007 11:22:25 AM


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